McKinney's Cotton Pickers were an influential American jazz band founded in Detroit, Michigan, in 1926 by Bill McKinney, who expanded his Synco Septet to a ten-piece ensemble. The band quickly rose to prominence, becoming one of the most popular African American bands from 1927 to 1931, with many of their records for Victor becoming bestsellers. In 1927, Don Redman, a notable arranger and saxophone player from Fletcher Henderson's band, joined as the musical director, significantly shaping the band's sound and repertoire. The ensemble included notable musicians such as Cuba Austin, Langston Curl, and Todd Rhodes, among others.

Throughout their peak years, McKinney's Cotton Pickers were known for their vibrant recordings and performances, which featured a mix of jazz and dance band styles. The band also collaborated with prominent soloists like Fats Waller and Coleman Hawkins during recording sessions. Despite their success, the band disbanded in 1934 due to financial difficulties during the Great Depression.

In the early 1970s, a new version of McKinney's Cotton Pickers was formed by David Hutson, utilizing Don Redman's arrangements. This revival included original member Dave Wilborn and recorded several albums, contributing to the preservation and celebration of the band's legacy well into the 1990s.