Lew Spence (June 29, 1920, Cedarhurst, New York – January 9, 2008, Los Angeles, California) was an American songwriter known for his contributions to popular music. Despite having little formal musical training, Spence led a dance band in his hometown as a teenager. In his twenties, he played piano and sang, but it wasn't until he was nearly 30 that he began publishing his songs. Initially focused on writing melodies, Spence shifted towards writing lyrics by the late 1950s.

One of his most renowned songs, "Nice 'n' Easy," was recorded by Frank Sinatra, with Spence composing the melody and Alan Bergman and Marilyn Keith writing the lyrics. The song received three Grammy Award nominations in 1960. Another notable work, "That Face," was first recorded by Fred Astaire in 1957 and performed by him on "Another Evening with Fred Astaire" in 1959. The song was later covered by artists such as Rosemary Clooney and Barbra Streisand, with Spence co-writing the lyrics with Alan Bergman, inspired by an encounter with actress Phyllis Kirk.

Spence's repertoire also includes standards like "Half as Lovely (Twice as True)," "If I Had Three Wishes," "Love Looks So Well on You," and "So Long My Love," recorded by prominent artists such as Dean Martin, Tony Bennett, Bobby Short, Peggy Lee, Nat King Cole, Johnny Mathis, Bing Crosby, Billy Eckstine, and Dinah Shore. In the 1980s, he collaborated with Burton Lane on a musical project that remained unfinished.