Cosimo Di Ceglie (October 21, 1913 – 1980) was an Italian jazz guitarist born in Andria, Italy. He began his musical career playing with local bands in his hometown before moving to Milan in the mid-1930s. There, he joined Herb Flemming's group and recorded with Piero Rizza and the Orchestra del Circolo Jazz Hot di Milano. Di Ceglie also led his own groups during this period.

In the late 1930s and early 1940s, he collaborated with notable musicians such as Enzo Ceragioli and Gorni Kramer, forming a jazz trio known as "I tre negri." During World War II, Di Ceglie remained active on radio, performing with a six-piece ensemble. After the war, he continued to record music under his own name throughout the late 1940s and 1950s.

Later in his career, Di Ceglie worked with artists like Adriano Celentano and Kai Hyttinen. Despite being less active after the war, his contributions to Italian jazz were significant, and he left a lasting impact on the genre. Di Ceglie passed away in Milan in 1980.