Byron Gregory, born on November 2, 1952, in Bronzeville, Chicago, is a renowned guitarist known for his work as a session and support musician. His family moved to Chicago from Georgia and Mississippi, seeking better opportunities and escaping the oppressive Jim Crow laws. Gregory's early exposure to music was influenced by his family's connection to blues singer Koko Taylor, who reportedly cared for him as a baby.

Gregory's musical journey began with a Silvertone acoustic guitar gifted by his grandparents, and he received music lessons from bassist Larry Kent. Despite his initial reluctance to learn music theory, Gregory honed his skills by playing popular songs by ear and performing at local talent shows. His early career was marked by collaborations with producer Clarence Johnson and the group Patti & the Lovelites.

Throughout his career, Byron Gregory has played with legendary artists across various genres, including soul, jazz, funk, and gospel. He is particularly noted for his work with Ramsey Lewis, contributing to the album "Sun Goddess" and touring with Earth, Wind & Fire. Gregory's subtle and effective guitar style has made him a sought-after session musician on Chicago's "Record Row," alongside other notable musicians like Phil Upchurch and Pete Cosey.

Despite his significant contributions to the music industry, Gregory often remained just outside the spotlight, supporting giants like Ruby Andrews and Tyrone Davis. His compositions, such as "Love Bandit" and "The Messenger," have been recorded by Ramsey Lewis, showcasing his talent as both a musician and a songwriter.